|
|
CMP-beta-Kdo + lipid_IVA_(E._coli) <=> alpha-Kdo-(2rarr6)-lipid_IVA_(E._coli) + CMP + H+
|
2.4.99.12
lipid IVA 3-deoxy-D-manno-octulosonic acid transferase
2.4.99.13
(Kdo)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase
|
–
–
|
| |
BRENDA:
BR49179;
BS402335;
BS423803
KEGG:
R04658
MetaCyc:
KDOTRANS-RXN
|
|
|
|
CMP-beta-Kdo + alpha-Kdo-(2rarr6)-lipid_IVA_(E._coli) <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid_IVA + CMP + H+
|
2.4.99.13
(Kdo)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase
|
–
|
| |
BRENDA:
BR49180;
BS422764
KEGG:
R05074;
R06285
MetaCyc:
KDOTRANS2-RXN
|
|
|
|
phosphatidylethanolamine + Kdo2-lipid_A <=> diacylglycerol + PEtN-KDO2-lipid_A
|
2.7.8.42
Kdo2-lipid A phosphoethanolamine 7''-transferase
|
–
|
| |
KEGG:
R11204
|
|
|
|
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O <=> UDP-3-O-((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine + acetate
|
3.5.1.108
UDP-3-O-acyl-N-acetylglucosamine deacetylase
|
–
|
| |
BRENDA:
BR49202
KEGG:
R04587
MetaCyc:
UDPACYLGLCNACDEACETYL-RXN
|
|
|
|
phosphatidylethanolamine + Kdo2-lipid_A_1-(2-aminoethyl_diphosphate) <=> diacylglycerol + Kdo2-lipid_A_1,4''-bis(2-aminoethyl_diphosphate)
|
2.7.8.43
lipid A phosphoethanolamine transferase
|
–
|
| |
KEGG:
R11557
|
|
|
|
dodecanoyl-[acyl-carrier_protein] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid_IVA <=> dodecanoyl-Kdo2-lipid_IVA + [acyl-carrier_protein]
|
2.3.1.241
Kdo2-lipid IVA lauroyltransferase
|
–
|
| |
BRENDA:
BS455136
KEGG:
R05146
MetaCyc:
LAUROYLACYLTRAN-RXN
|
|
|
|
1-PEtN-KDO-lipid_A + H2O <=> 4''-Dephosphorylated_1-PEtN-KDO-lipid_A + phosphate
|
3.1.3
|
–
|
| |
KEGG:
R12203
|
|
|
|
3-deoxy-D-manno-octulosonate + CTP <=> CMP-beta-Kdo + diphosphate
|
2.7.7.38
3-deoxy-manno-octulosonate cytidylyltransferase
|
–
|
| |
BRENDA:
BR48080
KEGG:
R03351
MetaCyc:
CPM-KDOSYNTH-RXN
|
|
|
|
D-glycero-beta-D-manno-heptose_1,7-bisphosphate + H2O <=> D-glycero-beta-D-manno-heptose_1-phosphate + phosphate
|
3.1.3.82
D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase
|
–
|
| |
BRENDA:
BR49195
KEGG:
R05647
MetaCyc:
RXN0-4361
|
|
|
|
CMP-beta-Kdo + alpha-Kdo-(2rarr6)-lipid_IVA_(E._coli) <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid_IVA + CMP + H+
|
2.4.99.13
(Kdo)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase
|
–
|
| |
BRENDA:
BR49180;
BS422764
KEGG:
R05074;
R06285
MetaCyc:
KDOTRANS2-RXN
|
|
|
|
4''-Dephosphorylated_1-PEtN-KDO-lipid_A + H2O <=> H._pylori_KDO-lipid_A + (R)-3-(Tetradecanoyloxy)hexadecanoic_acid
|
3.1.1
|
–
|
| |
KEGG:
R12204
|
|
|
|
4-amino-4-deoxy-alpha-L-arabinopyranosyl_undecaprenyl_phosphate + lipid_IVB <=> lipid_IIB + undecaprenyl_phosphate
|
2.4.2.43
lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase
|
–
|
| |
KEGG:
R12207
|
|
|
|
Kdo2-lipid_A + 2-oxoglutarate + O2 <=> (S)-2-Hydroxymyristate-modified_lipid_A + succinate + CO2
|
1.14.11
|
–
|
| |
KEGG:
R12210
|
|
|
|
tetradecanoyl-[acyl-carrier_protein] + dodecanoyl-Kdo2-lipid_IVA <=> Kdo2-lipid_A + [acyl-carrier_protein]
|
2.3.1.243
lauroyl-Kdo2-lipid IVA myristoyltransferase
|
–
|
| |
BRENDA:
BS454219
KEGG:
R05075
MetaCyc:
MYRISTOYLACYLTRAN-RXN
|
|
|
|
alpha-Kdo-(2rarr6)-lipid_IVA_(E._coli) + ATP <=> H+ + 4-O-phospho-alpha-Kdo-(2->6)-lipid_IVA + ADP
|
2.7.1.166
3-deoxy-D-manno-octulosonic acid kinase
|
–
|
| |
KEGG:
R09767
MetaCyc:
RXN-11328
|
|
|
|
3-deoxy-D-manno-octulosonate_8-phosphate + H2O <=> 3-deoxy-D-manno-octulosonate + phosphate
|
3.1.3.45
3-deoxy-manno-octulosonate-8-phosphatase
|
–
|
| |
BRENDA:
BR48154
KEGG:
R03350
MetaCyc:
KDO-8PPHOSPHAT-RXN
|
|
|
|
H2O + UDP-2,3-bis((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine <=> H+ + lipid_X_(E._coli) + UMP
|
3.6.1.54
UDP-2,3-diacylglucosamine diphosphatase
|
–
|
| |
BRENDA:
BR49205
KEGG:
R04549
MetaCyc:
LIPIDXSYNTHESIS-RXN
|
|
|
|
phosphatidylethanolamine + 1-dephosphorylated_Kdo2-lipid_A <=> diacylglycerol + 1-PEtN-KDO2-lipid_A
|
2.7.8.43
lipid A phosphoethanolamine transferase
|
–
|
| |
KEGG:
R12202
|
|
|
|
ADP-D-glycero-D-manno-heptose <=> ADP-L-glycero-D-manno-heptose
|
5.1.3.20
ADP-glyceromanno-heptose 6-epimerase
|
–
|
| |
BRENDA:
BR196
KEGG:
R05176
MetaCyc:
5.1.3.20-RXN
SABIO-RK:
4793
|
|
|
|
D-glycero-alpha-D-manno-heptose_1,7-bisphosphate + H2O <=> D-glycero-alpha-D-manno-heptose_1-phosphate + phosphate
|
3.1.3.83
D-glycero-alpha-D-manno-heptose 1,7-bisphosphate 7-phosphatase
|
–
|
| |
BRENDA:
BR49196
KEGG:
R09771
MetaCyc:
RXN-11365
|
|
|
|
tetradecanoyl-[acyl-carrier_protein] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(palmitoleoyl)-lipid_IVA <=> Palmitoleoyl-myristoyl-KDO2-lipid_A + [acyl-carrier_protein]
|
2.3.1.243
lauroyl-Kdo2-lipid IVA myristoyltransferase
|
–
|
| |
KEGG:
R12197
MetaCyc:
MYRPALMTRAN-RXN
|
|
|
|
palmitoyl-[acyl-carrier_protein] + H._pylori_KDO2-lipid_IVA <=> Stearoyl-KDO2-lipid_IVA + [acyl-carrier_protein]
|
2.3.1
|
–
|
| |
KEGG:
R12193
|
|
|
|
sedoheptulose_7-phosphate <=> D-glycero-alpha-D-manno-heptose_7-phosphate
|
5.3.1.28
D-sedoheptulose 7-phosphate isomerase
|
–
|
| |
KEGG:
R09769
|
|
|
|
lipid_X_(E._coli) + UDP-2,3-bis((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine <=> H+ + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(beta-D-1,6-)-2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl_beta-phosphate + UDP
|
2.4.1.182
lipid-A-disaccharide synthase
|
–
|
| |
BRENDA:
BR47523
KEGG:
R04606
MetaCyc:
LIPIDADISACCHARIDESYNTH-RXN
|
|
|
|
Kdo2-lipid_A + H2O <=> 3''-O-Deacylated_KDO2-lipid_A + (R)-3-(Tetradecanoyloxy)tetradecanoic_acid
|
3.1.1
|
–
|
| |
KEGG:
R12196
|
|
|
|
palmitoleoyl-[acyl-carrier_protein] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid_IVA <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(palmitoleoyl)-lipid_IVA + [acyl-carrier_protein]
|
2.3.1.242
Kdo2-lipid IVA palmitoleoyltransferase
|
–
|
| |
BRENDA:
BS427337
KEGG:
R10906
MetaCyc:
PALMITOTRANS-RXN
|
|
|
|
D-arabinose_5-phosphate <=> D-ribulose_5-phosphate
|
5.3.1.13
arabinose-5-phosphate isomerase
|
–
|
| |
BRENDA:
BR222
KEGG:
R01530
MetaCyc:
DARAB5PISOM-RXN
SABIO-RK:
1696
|
|
|
|
H._pylori_KDO2-lipid_A + H2O <=> 1-dephosphorylated_Kdo2-lipid_A + phosphate
|
3.1.3
|
–
|
| |
KEGG:
R12201
|
|
|
|
D-glycero-alpha-D-manno-heptose_7-phosphate + ATP <=> D-glycero-alpha-D-manno-heptose_1,7-bisphosphate + ADP
|
2.7.1.168
D-glycero-alpha-D-manno-heptose-7-phosphate kinase
|
–
|
| |
BRENDA:
BR49242
KEGG:
R09770
|
|
|
|
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + Deacyl-lipid_IVA <=> 2-acylglycerophosphocholine + Deacyl-lipid_IVB
|
2.3.1.251
lipid IVA palmitoyltransferase
|
–
|
| |
KEGG:
R12200
|
|
|
|
lipid_IVA_(E._coli) + 4-amino-4-deoxy-alpha-L-arabinopyranosyl_undecaprenyl_phosphate <=> lipid_IIA + undecaprenyl_phosphate
|
2.4.2.43
lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase
|
–
|
| |
BRENDA:
BR49177
KEGG:
R09773
MetaCyc:
RXN-12366
|
|
|
|
phosphoenolpyruvate + D-arabinose_5-phosphate + H2O <=> 3-deoxy-D-manno-octulosonate_8-phosphate + phosphate
|
2.5.1.54
3-deoxy-7-phosphoheptulonate synthase
2.5.1.55
3-deoxy-8-phosphooctulonate synthase
|
–
–
|
| |
BRENDA:
BR47464
KEGG:
R03254
SABIO-RK:
3075
|
|
|
|
phosphatidylethanolamine + Kdo2-lipid_A <=> diacylglycerol + Kdo2-lipid_A_1-(2-aminoethyl_diphosphate)
|
2.7.8.43
lipid A phosphoethanolamine transferase
|
–
|
| |
KEGG:
R11555
|
|
|
|
2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(beta-D-1,6-)-2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl_beta-phosphate + ATP <=> H+ + lipid_IVA_(E._coli) + ADP
|
2.7.1.130
tetraacyldisaccharide 4'-kinase
|
–
|
| |
BRENDA:
BR47743
KEGG:
R04657
MetaCyc:
TETRAACYLDISACC4KIN-RXN
|
|
|
|
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid_IVA_(E._coli) <=> 2-acylglycerophosphocholine + lipid_IVB
|
2.3.1.251
lipid IVA palmitoyltransferase
|
–
|
| |
BRENDA:
BR51522
KEGG:
R12187
MetaCyc:
RXN-16275
|
|
|
|
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid_IIA <=> 2-acylglycerophosphocholine + lipid_IIB
|
2.3.1.251
lipid IVA palmitoyltransferase
|
–
|
| |
BRENDA:
BR51521
KEGG:
R12206
MetaCyc:
RXN-16274
|
|
|
|
2,3,2''3''-Tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine_1,4''-bisphosphate + H2O <=> Deacyl-lipid_IVA + (R)-3-Hydroxymyristic_acid
|
3.1.1
|
–
|
| |
KEGG:
R12199
|
|
|
|
H+ + D-glycero-beta-D-manno-heptose_1-phosphate + ATP <=> ADP-D-glycero-D-manno-heptose + diphosphate
|
2.7.7.70
D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase
|
–
|
| |
BRENDA:
BR49189
KEGG:
R05644
MetaCyc:
RXN0-4342
|
|
|
|
1-PEtN-KDO2-lipid_A + H2O <=> 1-PEtN-KDO-lipid_A + 3-deoxy-D-manno-octulosonate
|
3.2.1.144
3-deoxyoctulosonase
|
–
|
| |
KEGG:
R12219
|
|
|
|
H+ + D-glycero-alpha-D-manno-heptose_1-phosphate + GTP <=> GDP-D-glycero-alpha-D-manno-heptose + diphosphate
|
2.7.7.71
D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase
|
–
|
| |
BRENDA:
BR49190
KEGG:
R09772
MetaCyc:
RXN-11363
|
|
|
|
UDP-N-acetyl-D-glucosamine + (3R)-3-hydroxymyristoyl-[acyl-carrier_protein] <=> UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + [acyl-carrier_protein]
|
2.3.1.129
acyl-[acyl-carrier-protein]---UDP-N-acetylglucosamine O-acyltransferase
|
–
|
| |
KEGG:
R04567
MetaCyc:
UDPNACETYLGLUCOSAMACYLTRANS-RXN
|
|
|
|
lipid_IVB + H2O <=> Deacyl-lipid_IVB + (R)-3-Hydroxymyristic_acid
|
3.1.1
|
–
|
| |
KEGG:
R12198
|
|
|
|
(3R)-3-hydroxymyristoyl-[acyl-carrier_protein] + UDP-3-O-((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine <=> UDP-2,3-bis((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine + [acyl-carrier_protein] + H+
|
2.3.1.191
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase
|
–
|
| |
BRENDA:
BR49174
KEGG:
R04550
MetaCyc:
UDPHYDROXYMYRGLUCOSAMNACETYLTRANS-RXN
|
|
|
|
D-glycero-beta-D-manno-heptose_7-phosphate + ATP <=> D-glycero-beta-D-manno-heptose_1,7-bisphosphate + ADP
|
2.7.1.167
D-glycero-beta-D-manno-heptose-7-phosphate kinase
|
–
|
| |
BRENDA:
BR49187;
BS436962
KEGG:
R05646
|
|
|
|
4-amino-4-deoxy-alpha-L-arabinopyranosyl_undecaprenyl_phosphate + Kdo2-lipid_A <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-[4-P-L-Ara4N]-lipid_A + undecaprenyl_phosphate
|
2.4.2.43
lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase
|
–
|
| |
BRENDA:
BR49533
KEGG:
R09781
|
|
|
|
tetradecanoyl-[acyl-carrier_protein] + Stearoyl-KDO2-lipid_IVA <=> H._pylori_KDO2-lipid_A + [acyl-carrier_protein]
|
2.3.1
|
–
|
| |
KEGG:
R12194
|
|
|
|
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + Kdo2-lipid_A <=> 2-acylglycerophosphocholine + C16-KDO2-lipid_A
|
2.3.1.251
lipid IVA palmitoyltransferase
|
–
|
| |
KEGG:
R12211
MetaCyc:
RXN-20918
|
|
|
|
sedoheptulose_7-phosphate <=> D-glycero-beta-D-manno-heptose_7-phosphate
|
5.3.1.28
D-sedoheptulose 7-phosphate isomerase
|
–
|
| |
KEGG:
R05645
|
|
|
|
Kdo2-lipid_A + undecaprenyl_diphosphate <=> KDO2-lipid_A_1-diphosphate + undecaprenyl_phosphate
|
2.7.4.29
Kdo2-lipid A phosphotransferase
|
–
|
| |
KEGG:
R11186
MetaCyc:
RXN-16281
|
|
